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Measurement of glutamate Cells were collected in phosphate buffer (100 mM sodium phosphate, 1 mM ethylene diamine tetraacetate, pH 7.5) and sonicated and lysates centrifuged to remove insoluble debris

Similarly, in a diabetic neuropathy mouse model, topiramate administration (10 or 30 mg/kg) led to a significant, dose-dependent reduction in spinal cord levels of TNF- and IL-1 (Motaghinejad et al., 2016)

Although, it is unclear whether sarcosine is the cause or the effect, our findings support a link between the low sarcosine levels with cognitive dysfunction and depression scores in LC patients

In particular, glutathione protects cells by neutralizing the effects of reactive hydroxyl free radicals and other oxygen-derived free radicals

PMID 24886657